Symbolic Systems Forum
Title: How Does the Human Brain Build Itself?
Speaker: Sergiu Pasca, Psychiatry and Behavioral Sciences Department
Date: January 24
Time: 4:30 PM - 5:20 PM
Location: Margaret Jacks Hall (Bldg. 460), Room 126
A critical challenge in understanding the programs underlying development, assembly and disease of the human brain is the lack of direct access to intact, functioning human neural tissue for detailed investigation and manipulation. In my talk, I will first describe how my laboratory has been leveraging instructive signals to develop, starting from human pluripotent stem cells, self-organizing neural organoids resembling specific domains of the nervous system. I will next introduce a self-organizing cellular preparation named an assembloid that we created to model cell migration and circuit in the developing human nervous system. Lastly, I will illustrate how organoids and assembloids can be used to study development, evolution and to model genetic neuropsychiatric disease both in vitro as well as in living systems.